Epigenetics Research Tools
Epigenetics Research Tools
Innovative technologies and products to facilitate epigenetics research and expand the potential for biomarker discovery
Epigenetics is the study of chromatin-based phenomena and heritable changes in gene expression that do not involve changes to the underlying DNA sequence - a change in phenotype without a change in genotype. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle and disease state. Researchers can start out with little more than DNA, histone proteins or chromatin and investigate fascinating topics such as cancer epigenetics, neuropsychiatric disorders, nutritional development, metabolic diseases and more.
Innovative technologies and products developed by our partners EpigenTek and EpiCypher including kits for the analysis of DNA methylation and chromatin remodeling are offered.
Sample Preparation Kits
DNA Methylation Kits
Choose from a large number of kits developed for gene-specific or global DNA methylation analysis.
RNA Methylation Kits
Analyze m6A or 5-mC RNA methylation in total RNA samples isolated from cells or tissue.
Histone Modification Kits
Screen and measure different H3 or H4 modifications in ELISA-like kits.
Recombinant histone proteins are the building block of nucleosomes, and an essential reagent in chromatin research. EpiCypher offers highly pure recombinant histone proteins, including canonical histones (H2A, H2B, H3 and H4) and histone variants, such as H2AZ.1, H2AZ.2 and H2AX.
Histone Binding Domains
Use recombinant histone binding domains, including bromodomains and YEATS domains, in a variety of downstream applications.
Histone Peptide Arrays
Quickly screen for histone H3 specificity of antibodies, proteins and enzymes.
Histone Modification Peptides
Choose from the largest selection of histone peptides, many modifications, single or multiple.
Purified and Recombinant Nucleosomes
Employ fully defined and homogeneous recombinant nucleosomes incorporating different DNA and histone modifications, site mutations, and histone variants. More than 70 post translational modifications (PTM) available.
Gain further insight into the dynamic interactions between transcription proteins and components of chromatin by using chromatin immunoprecipitation (ChIP).
EpiDyne Chromatin Remodeling Assay Substrates
Study chromatin remodeling using EpiDyne nucleosome substrates available for three readouts: Restriction Enzyme Accessibility (REA), FRET and Radiometric DAM methyltransferase assays.
Site-specific Chromatin Loop Formation by dCas9
Study the dynamic effects of chromatin structure on gene expression.
Epigenomic Profiling with Next Generation Sequencing
Construct high-quality NGS libraries from low quantity or difficult samples for Genomic DNA Seq, DNA Bisulfite Seq, ChIP Seq, Post Bisulfite Seq or RNA Bisulfite Seq.