Mutant Nucleosomes (Acidic Patch Nucs)
Mutant Nucleosomes (Acidic Patch Nucs)
Ideal Substrates for Functional Studies
- Three unique Acidic Patch Mutant Nucs available
- Define multivalent interactions involving the acidic patch
- Useful for drug / inhibitor development and HTS
- Valuable controls for structural analysis
The nucleosome acidic patch refers to a small set of negatively charged amino acids clustered on the surface of the nucleosome disk, at the interface of histones H2A and H2B. This patch serves as a central binding site for many chromatin binding proteins, including nucleosome remodeling complexes, and has emerged as a key regulator of multivalent chromatin interactions. The acidic patch has also been shown to modulate high-order chromatin folding and condensation through extensive interactions with histone tails.
EpiCypher Acidic Patch Mutant Nucs have defined mutations in the acidic patch, and are useful substrates for biochemical studies, drug development, and more.
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