The relationship between cells and their relative locations within tissue is critical to understanding normal development and disease pathology. Spatial transcriptomics is a groundbreaking molecular profiling method that allows scientists to measure all the gene activity in a tissue sample and map where the activity is occurring.
We offer Spatial Profiling Services on NanoString GeoMx and the 10x Visium Spatial Platform from our partner BioChain who is a GeoMx Premier Access site. Customers can send their sample slides for processing to us and conveniently obtain spatial profiling information using the NanoString GeoMx Digital Spatial Profiler (DSP) instrument. BioChain specializes in providing a fully customizable, end-to-end, full stack process with in-house tissues, histopathology team services, digital Leica scanning, and an expert NGS data analysis team to fulfill all of your research needs.
The NanoString GeoMx Digital Spatial Profiling platform enables the measurement of patterns of gene expression in specific targeted areas of interest on tumor sections (e.g., center of tumor, near tumor/normal tissue interface, areas of immune cell infiltration, etc.) to identify gene or pathway activation differences that may provide information on potential diagnostic markers or therapeutic targets. Investigators interested in understanding tumor biology and genetic drivers of metastasis, developing diagnostic and treatment prognosis assays, looking for genetic markers of drug susceptibility, and numerous other applications will find this technology invaluable.
NanoString and GeoMx are registered trademarks of NanoString Technologies, Inc.
The 10x Visium Technology is a next generation molecular profiling solution for classifying tissue based on total mRNA. Mapping gene expression by spatially resolving the whole transcriptome allows you to determine the function of distinct cell populations, explore how proximity affects biological response, identify new biomarkers, and profile distinct biological compartments.