Mutations in histone proteins occur in diverse cancer types but have been challenging to study in a physiological context. A recent large-scale study of more than 180 tumor types suggests that somatic histone mutations occur in 4% of cancers, highlighting novel epigenetic diversity that may be leveraged for future drug and biomarker development. EpiCypher’s Oncogenic Nucleosomes, or oncoNucs, are assembled using histones with cancer-associated mutations, providing highly relevant nucleosome substrates for cancer research.
Mutant Nucleosomes (Acidic Patch Nucs)