Bringing Epigenetics to Life
Our partner EpiCypher offers cutting-edge tools and services for epigenetics and chromatin biology research. EpiCypher pioneered the manufacture of designer recombinant nucleosomes that contain defined post-translational modifications. Their SNAP-ChIP, is the gold standard for antibody validation for chromatin IP, and also serves as the most reproducible spike-in for normalizing ChIP and ChIP-seq assays.
CUTANA ChIC / CUT&RUN and CUT&Tag Assays combine antibody-targeted controlled cleavage with massively parallel DNA sequencing to identify the binding sites of DNA-associated proteins with high resolution, at a fraction of the time and cost of standard ChIP-seq experiments.
EpiCypher also develops assays for chromatin-modifying enzymes and PTM-binding proteins using a variety of readouts, such as Alpha, FRET and radioactivity, employing nucleosome or peptide-based substrates.