FOXA1/HNF3A Antibody: CUTANA Compatible (CUT&RUN)

CUTANA Compatible Antibodies meet the criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping.

Data sheet

Product Description

FOXA1 antibody produces CUT&RUN peaks above background primarily in intronic, intergenic, and promoter regions (Figure 1) that overlap with known FOXA1 DNA-binding motifs.

13 2001 Heatmap 500

Figure 1: FOXA1 peaks in CUT&RUN. CUT&RUN was performed using 500,000 MCF7 cells with 0.5 µg FOXA1 antibody. Peaks were called using MACS2. (A) Heatmap showing FOXA1 peaks relative to IgG negative control antibody (EpiCypher 13-0042) in aligned rows ranked by intensity (top to bottom) and colored such that red indicates high localized enrichment and blue denotes background signal. (B) The number of peaks which fall into distinct classes of functionally annotated genomic regions is plotted.

Every lot of a CUTANA Compatible antibody is tested in the indicated CUTANA approach using EpiCypher optimized protocols and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein.

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    Blue Ice
  • Price
  • 599,00 €
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Dr. Sieke Schaepe

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