CUTANA Compatible Antibodies meet the criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping.

Data sheet

Product Description

CHD1 antibody produces CUT&RUN peaks above background that overlap with H3K4me3 (Figure 1), consistent with CHD1 tandem chromodomains that mediate H3K4me3 binding and SWI/SNF complex nucleosome remodeling (1).

13 2008 Heatmap 300

Figure 1: CHD1 enrichment at annotated transcription start sites (TSSs) in CUT&RUN. CUT&RUN was performed using 500,000 K562 cells with CHD1 and control antibodies (0.5 µg each; IgG negative control, EpiCypher 13-0042; H3K4me3 positive control, EpiCypher 13-0041). Sequencing reads were aligned to annotated TSSs (+/- 2 kbp) of 18,793 genes. High, medium, and low signal is ranked by intensity (top to bottom) and reflected by red, yellow, and blue colors, respectively. Rows aligned relative to CHD1 antibody.

Every lot of a CUTANA Compatible antibody is tested in the indicated CUTANA approach using EpiCypher optimized protocols and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein.


1. Flanagan et al (2005) Nature 7071:1181-5

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