FADD Antibody (Clone T1B)Datasheet
|Reactivity:||Human, mouse, dog|
|Applications:||Western blot, Immunofluorescence|
|Synonyms:||FAS-associated death domain protein, GIG3, mgC8528, MORT1|
Recombinant human FADD
Western blot analysis (1-4 ug/ml). The antibody detects 28 kDa protein, corresponding to the apparent molecular weight of FADD in SDS-PAGE However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.immunoblots from samples of human and mouse origins.
Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 24 kDa cytosolic protein. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that can be inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death.