FADD Antibody (Clone T1B)

Datasheet
Specifications
Clonality: Monoclonal
Host: Mouse
Reactivity: Human, mouse, dog
Applications: Western blot, Immunofluorescence
Additional Information
Synonyms: FAS-associated death domain protein, GIG3, mgC8528, MORT1
Gene Symbol: FADD
Organism: Homo sapiens
Gene ID: 8772
UniProt ID: NM_003824

Immunogen

Recombinant human FADD

Application

Western blot analysis (1-4 ug/ml). The antibody detects 28 kDa protein, corresponding to the apparent molecular weight of FADD in SDS-PAGE However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.immunoblots from samples of human and mouse origins.

Background

Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 24 kDa cytosolic protein. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that can be inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death.

  • Catalog Number
    3008-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 388,00 €
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