Caspase-8 Antibody

Datasheet
Specifications
Clonality: Polyclonal
Host: Rabbit
Reactivity: mouse, rat, bovine, monkey
Applications: Western blot
Additional Information
Synonyms: CASP8 , mgC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC 3.4.22.61
Gene Symbol: Casp8
Organism: Mus musculus
Gene ID: 12370
UniProt ID: BC006737

Immunogen

Synthetic peptide surrounding amino acid 392 of mouse caspase-8

Application

Western blotting (0.5-4 ug/ml). The immunoaffinity purified antibody detects the full length (55 kDa), intermediate cleavage fragments (26-31 kDa) and cleaved large fragment (18 kDa) of caspase-8.

Background

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.

  • Catalog Number
    3020-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 414,00 €
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