Caspase-11 Antibody

Clonality: Polyclonal
Host: Rabbit
Reactivity: Mouse, rat
Applications: Western blot
Additional Information
Synonyms: CASP-11, ICEB,ICH-3
Gene Symbol: Casp4
Organism: Mus musculus
Gene ID: 12363
UniProt ID: NM_007609


Synthetic peptide surrounding amino acid 257 of rat caspase-11


Western blotting (0.5-4 ug/ml). The antibody detects procaspase-11 (45 kDa), a partially cleaved fragment (30 kDa) and fully cleaved fragment (20 kDa). A 58 kDa unknown identity band was also detected in 3T3 cells.


Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-11 is also synthesized as inactive pro-enzyme that are processed in cells undergoing apoptosis or inflammation. The processed form of caspase-11 consists of large and small subunits which associate to form an active enzyme.

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