PARP Antibody (Clone 7A10)

Datasheet
Specifications
Clonality: Monoclonal
Host: Mouse
Reactivity: Human
Applications: Western blot, Immunocytochemistry
Additional Information
Synonyms: PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1
Gene Symbol: PARP1
Organism: Homo sapiens
Gene ID: 142
UniProt ID: P09874

Application

The antibody performs well on Western blot (1:500-1:2000) and Flow Cytometry studies (1:200-1:400).

Background

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability, cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

  • Catalog Number
    3023-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 419,00 €
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