Mcl-1 Antibody

Clonality: Polyclonal
Host: Rabbit
Reactivity: Human, mouse, rat, monkey
Applications: Western blot, Immunoprecipitation, Immunohistochemistry
Additional Information
Synonyms: MCL1L, mcl1/EAT, mgC1839, mgC104264, TM, MCL1S, EAT
Gene Symbol: MCL1
Organism: Homo sapiens
Gene ID: 4170
UniProt ID: Q07820


Synthetic peptide corresponding to residues surrounding amino acid 131 of human Mcl-1


Western blot analysis (0.5-4 ug/ml), immunoprecipitation (10-20 ug/ml), and Immunohistochemistry (10-20 ug/ml). However, the optimal conditions should be determined individually.


Mcl-1 (Myeloid cell leukemia-1) is a 37 kDa Bcl-2-related protein with an apparent molecular weight of 43 kDa on SDS-PAGE. Mcl-1 was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-β1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.

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