RAIDD Antibody

Datasheet
Specifications
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human, mouse, rat
Applications: Western blot
Additional Information
Synonyms: CRADD, mgC9163,
Gene Symbol: CRADD
Organism: Homo sapiens
Gene ID: 8738
UniProt ID: AAH37905

Immunogen

Synthetic peptide surrounding amino acid 171 of human RAIDD

Application

Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody detects a 22 kDa band, corresponding to the expected molecular mass of RAIDD on immunoblots.

Background

Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. The complex processes procaspase-9 into a large subunit (35 kDa or 17-25 kDa) and small (10 kDa) by self-cleavage at D315. Activated caspase-9 further cleaves other caspase members including caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. In addition to self-cleavage, procaspase-9 can also be cleaved in vivo by caspase-3 at D330. The process served as a positive feedback to amplify the apoptotic signal in caspase activation pathway.

  • Catalog Number
    3037-30T-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 219,00 €
Add to Cart
you need any help?

Please contact:

Dr. Monika Haas

Tel. +49 (0) 6221 714 15 16 info@biocat.com