|Reactivity:||Human, Mouse and Rat|
|Synonyms:||Inositol-tetrakisphosphate 1-kinase, Inositol 1.3.4-trisphosphate 5/6-kinase, Inositol-triphosphate 5/6-kinase, Ins(1.3.4)P(3) 5/6-kinase|
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ITPK1
WB, 1:500 – 1:2000
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.