Anti-IL-16 Antibody

Datasheet
Specifications
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Applications: WB
Additional Information
Synonyms: Pro-interleukin-16
Gene Symbol: IL16
Organism: Homo sapiens
Gene ID: 3603
UniProt ID: Q14005

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human IL-16

Application

WB, 1:500 – 1:2000

Background

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

  • Catalog Number
    A1413-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 434,00 €
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