Anti-AMACR / p504S Antibody (AMACR/1723)

Datasheet
Specifications
Clonality: Monoclonal
Host: Mouse
Reactivity: Human
Applications: IF, IHC
Additional Information
Synonyms: Alpha-methylacyl-CoA Racemase, CBAS4, Da1-8, Macr1, RACE, RM
Gene Symbol: AMACR
Organism: Homo sapiens
Gene ID: 23600
UniProt ID: Q9UHK6

Immunogen

Recombinant human full-length AMACR protein

Application

IF: 1-2 ug/ml, IHC: 1-2 ug/ml

Background

This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and β-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.

  • Catalog Number
    A1428-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 492,00 €
Add to Cart
you need any help?

Please contact:

Dr. Monika Haas

Tel. +49 (0) 6221 71415 16 info@biocat.com