Anti-BRCA1 Antibody (BRCA1/1398)

Datasheet
Specifications
Clonality: Monoclonal
Host: Mouse
Reactivity: Human
Applications: FC, IF, IHC
Additional Information
Synonyms: BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53
Gene Symbol: BRCA1
Organism: Homo sapiens
Gene ID: 672
UniProt ID: P38398

Immunogen

Recombinant human BRCA1 protein fragment (aa445-620)

Application

FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, IHC: 5-10 ug/ml

Background

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

  • Catalog Number
    A1448-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 492,00 €
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Dr. Monika Haas

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