Anti-PD-L1 Antibody

Datasheet
Specifications
Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Applications: WB
Additional Information
Synonyms: PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Gene Symbol: CD274
Organism: Homo sapiens
Gene ID: 29126
UniProt ID: Q9NZQ7

Immunogen

Recombinant human PD-L1

Application

WB: 1-4 ug

Background

Programmed death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

  • Catalog Number
    A1454-30T-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 220,00 €
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