|Reactivity:||Human, Mouse, Rat|
|Synonyms:||Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved), Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved)|
Human recombinant Irisin
WB: 1-4 ug
Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1, a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.