Anti-Irisin Antibody

Clonality: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
Additional Information
Synonyms: Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved), Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved)
Gene Symbol: FNDC5
Organism: Homo sapiens
Gene ID: 252995
UniProt ID: Q8NAU1


Human recombinant Irisin


WB: 1-4 ug


Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1, a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.

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    Blue Ice
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  • 220,00 €
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