Anti-SEC61B (KO Validated) AntibodyDatasheet
|Applications:||Immunofluorescence (IF),Western Blotting|
Synthetic peptide targeting a sequence around aa 1-96 of human SEC61B
WB 1:500 - 1:2000, IF 1:50 - 1:200
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple poly-adenylated sites for this transcript.