Anti-IL-6 (Siltuximab), Chimeric Antibody

Clonality: Monoclonal
Host: Human/Mouse chimeric
Reactivity: Human
Additional Information
Synonyms: CLLB8, CNTO 328, CNTO-328, CNTO328, Sylvant, IL6, IL 6, IL-6
UniProt ID: DB09036




Siltuximab is a chimeric (human-murine) IgG1 kappa monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. This antibody binds to and neutralizes human IL-6, inhibits IL-6 binding to its receptor, and subsequent IL-6 signaling. Siltuximab was developed by Janssen Biotech and received FDA approval in 2014 to treat patients suffering from multicentric Castleman’s disease, but are negative for HIV and HHV-8. This monoclonal antibody has recently been investigated for the treatment of various forms of cancer such as metastatic renal cell cancer, ovarian cancer, and prostate cancer. Siltuximab is marketed under the brand name of SYLVANT™

  • Catalog Number
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    Blue Ice
  • Price
  • 555,00 €
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