Anti-IL-4Rα (Dupilumab), Human IgG4 Antibody

Clonality: Monoclonal
Host: Recombinant
Reactivity: Human
Applications: In vitro studies
Additional Information
Synonyms: CD124, REGN668, REGN 668, REGN-668, SAR231893, SAR 231893, SAR-231893
UniProt ID: DB12159


Human IL-4Rα


In vitro studies


The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets IL-4Rα and inhibits IL-4 and IL-13 signaling, which play an important role in Th-2 mediated immune response and thus downregulates Type 2 inflammation. The biosimilar was generated in CHO cells using recombinant DNA technology. The original drug was developed by Sanofi and Regeneron and received approval from the FDA for the treatment of atopic dermatitis and eczema. Additionally, this drug received approval to treat patients aged 12 years and above, suffering from moderate-to-severe asthma, and moderate-to-severe eosinophilic asthma or oral corticosteroid-dependent asthma.

  • Catalog Number
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    Blue Ice
  • Price
  • 555,00 €
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