Anti-IL-4Rα (Dupilumab), Human IgG4 Antibody

Datasheet
Specifications
Clonality: Monoclonal
Host: Recombinant
Reactivity: Human
Applications: In vitro studies
Additional Information
Synonyms: CD124, REGN668, REGN 668, REGN-668, SAR231893, SAR 231893, SAR-231893
UniProt ID: DB12159

Immunogen

Human IL-4Rα

Application

In vitro studies

Background

The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets IL-4Rα and inhibits IL-4 and IL-13 signaling, which play an important role in Th-2 mediated immune response and thus downregulates Type 2 inflammation. The biosimilar was generated in CHO cells using recombinant DNA technology. The original drug was developed by Sanofi and Regeneron and received approval from the FDA for the treatment of atopic dermatitis and eczema. Additionally, this drug received approval to treat patients aged 12 years and above, suffering from moderate-to-severe asthma, and moderate-to-severe eosinophilic asthma or oral corticosteroid-dependent asthma.

  • Catalog Number
    A2148-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 555,00 €
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Dr. Monika Haas

Tel. +49 (0) 6221 71415 16 info@biocat.com