Anti-CD30 (Brentuximab Vedotin), Chimeric Antibody

Datasheet
Specifications
Clonality: Monoclonal
Host: Human/Mouse chimeric
Reactivity: Human
Additional Information
Synonyms: cAC10-vcMMAE, SGN 35, SGN-35, Ki-1, D1S166E, TNFRSF8
UniProt ID: DB08870

Immunogen

Human CD30

Background

The research-grade biosimilar is an antibody-drug conjugate that targets CD30. The conjugate consists of an Anti-CD30 human-mouse chimeric IgG1 antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and results in apoptosis of tumorigenic cells. The original drug received approval from the FDA to treat adult patients with relapsed or refractory Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.

  • Catalog Number
    A2177-100-BV
  • Supplier
    BioVision
  • Size
  • Shipping
    Blue Ice
  • Price
  • 555,00 €
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Dr. Monika Haas

Tel. +49 (0) 6221 71415 16 info@biocat.com