TCHP Polyclonal Antibody

Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500
Label: Unconjugated
Additional Information
Synonyms: Trichoplein keratin filament-binding protein, Protein TCHP, TCHP, Mitochondrial protein with oncostatic activity, Mitostatin, Tumor suppressor protein
UniProt ID: Q9BT92


Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).

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