TCHP Polyclonal Antibody
| Specifications | |
|---|---|
| Clonality: | Polyclonal |
| Host: | Rabbit |
| Reactivity: | Human |
| Applications: | ELISA, IHC, IF, Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500 |
| Label: | Unconjugated |
| Purification/Format: | Protein G purified |
| Additional Information | |
|---|---|
| Synonyms: | Trichoplein keratin filament-binding protein, Protein TCHP, TCHP, Mitochondrial protein with oncostatic activity, Mitostatin, Tumor suppressor protein |
| UniProt ID: | Q9BT92 |
Immunogen
Recombinant Human Trichoplein keratin filament-binding protein (1-498AA)
Background
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).