WDYHV1 Polyclonal Antibody, HRP Conjugated

Clonality: Polyclonal
Host: Rabbit
Reactivity: Human
Applications: ELISA
Label: HRP
Additional Information
Synonyms: Protein N-terminal glutamine amidohydrolase (EC:3.5.1.-), WDYHV1, C8orf32, NTAQ1, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, WDYHV motif-containing protein 1
UniProt ID: Q96HA8


Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

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