SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag
Datasheet| Specifications | |
|---|---|
| Molecular Weight: | 35.3 kDa (NSP16) & 18.3 kDa (NSP10) |
| Source: | SARS-CoV-2 NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag (NS0-C51W3) is expressed from E.coli cells. It contains AA Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10) (Accession # YP_009725311.1 (NSP16) & YP_009725306.1 (NSP10)). |
| Purity: | >90% as determined by SDS-PAGE. |
| Endotoxin Level: | Less than 1.0 EU per μg by the LAL method. |
| Format: | Liquid |
| Additional Information | |
|---|---|
| Synonyms: | NSP16 & NSP10,nsp16 & nsp10 |
| Organism: | Other |
| Acc.No.: | YP_009725311.1 (NSP16) & YP_009725306.1 |
Sequence Information
Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10)
Background
NSP10, Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and 2'-O-methyltransferase (NSP16) activities. Therefore plays an essential role in viral mRNAs cap methylation. 2'-O-methyltransferase (NSP16) that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities.
- Catalog Number
NS0-C51W3-1mg-AC - Supplier
ACROBiosystems - Size
- Shipping
Dry Ice
- Price
- 3.075,00 €