SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

Datasheet
Specifications
Molecular Weight: 35.3 kDa (NSP16) & 18.3 kDa (NSP10)
Source: SARS-CoV-2 NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag (NS0-C51W3) is expressed from E.coli cells. It contains AA Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10) (Accession # YP_009725311.1 (NSP16) & YP_009725306.1 (NSP10)).
Purity: >90% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Liquid
Additional Information
Synonyms: NSP16 & NSP10,nsp16 & nsp10
Organism: Other
Acc.No.: YP_009725311.1 (NSP16) & YP_009725306.1

Sequence Information

Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10)

Background

NSP10, Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and 2'-O-methyltransferase (NSP16) activities. Therefore plays an essential role in viral mRNAs cap methylation. 2'-O-methyltransferase (NSP16) that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities.

  • Catalog Number
    NS0-C51W3-1mg-AC
  • Supplier
    ACROBiosystems
  • Size
  • Shipping
    Dry Ice
  • Price
  • 3.075,00 €
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