SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag

Molecular Weight: 21.7 kDa
Tag: His Tag
Source: SARS-CoV-2 NSP1, His Tag (NS1-C51H7) is expressed from E.coli cells. It contains AA Met 1 - Gly 180 (Accession # YP_009725297.1).
Purity: >90% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Powder
Additional Information
Synonyms: NSP1,nsp1,Leader protein,Host translation inhibitor nsp1
Organism: Other
Acc.No.: YP_009725297.1

Sequence Information

Met 1 - Gly 180


The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

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