SARS-CoV-2 Nucleocapsid protein (Q384H), His Tag

Molecular Weight: 47.3 kDa
Tag: His Tag
Source: SARS-CoV-2 Nucleocapsid protein (Q384H), His Tag (NUN-C52H4) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1 (Q384H)). The nucleocapsid protein is consisted of the N-terminal RNA-binding domain (NTD) and the C-terminal dimerization domain (CTD), divided by a central serine/arginine-rich (SR)-linker responsible for phosphorylation. The mutation Q384H was identified on the nucleocapsid protein of SARS-CoV-2 variants with high frequency (~7%) in variants circulating in Africa (data retrieved from
Purity: >90% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Powder
Additional Information
Synonyms: Nucleocapsid protein,NP,Protein N
Organism: Other
Acc.No.: QHO62115.1 (Q384H)

Sequence Information

Met 1 - Ala 419


Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

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