SARS-CoV-2 S1 protein NTD (L18F, T20N, P26S, D138Y, R190S), His Tag (MALS verified), Variant Lineage P.1
Datasheet| Specifications | |
|---|---|
| Molecular Weight: | 34.9 kDa |
| Tag: | His Tag |
| Source: | SARS-CoV-2 S1 protein NTD, His Tag (S1D-C52He) is expressed from human 293 cells (HEK293). It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1). The L18F/ T20N/ P26S/ D138Y/ R190S mutations were identified on the spike protein N-terminal domain (NTD) in the SARS-CoV-2 Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3). |
| Purity: | >90% as determined by SDS-PAGE. |
| Endotoxin Level: | Less than 1.0 EU per μg by the LAL method. |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | S1 protein NTD,Spike protein S1 NTD,BetaCoV S1-NTD |
| Organism: | Other |
| Acc.No.: | QHD43416.1 |
Sequence Information
Ser 13 - Leu 303
Background
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.