SARS-CoV-2 (COVID-19) S1 protein (HV69-70del, N501Y, D614G), His Tag, Variant Lineage B.1.1.7
Datasheet| Specifications | |
|---|---|
| Molecular Weight: | 76.7 kDa |
| Tag: | His Tag |
| Source: | SARS-CoV-2 S1 protein (HV69-70del, N501Y, D614G), His Tag (S1N-C52Hk) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1 (HV69-70del, N501Y, D614G)). HV69-70del / N501Y / D614G were identified in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01). |
| Purity: | >90% as determined by SDS-PAGE. |
| Endotoxin Level: | Less than 1.0 EU per μg by the LAL method. |
| Format: | Powder |
| Additional Information | |
|---|---|
| Synonyms: | Spike,S1 protein,Spike glycoprotein Subunit1,S glycoprotein Subunit1,Spike protein S1 |
| Organism: | Other |
| Acc.No.: | QHD43416.1 (HV69-70del,N501Y,D614G) |
Sequence Information
Val 16 - Arg 685
Background
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.