SARS-CoV-2 S2 protein (T716I, S982A, D1118H), His Tag, Variant Lineage B.1.1.7

Datasheet
Specifications
Molecular Weight: 59.6 kDa
Tag: His Tag
Source: SARS-CoV-2 S2 protein (T716I, S982A, D1118H), His Tag (S2N-C52Hd) is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P/ A892P/ A899P/ A942P/ K986P/ V987P) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein. The T716I/ S982A/ D1118H mutations were identified in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01).
Purity: >95% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Powder
Additional Information
Synonyms: Spike,S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2
Organism: Other
Acc.No.: QHD43416.1

Sequence Information

Ser 686 - Pro 1213

Background

It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

  • Catalog Number
    S2N-C52Hd-100ug-AC
  • Supplier
    ACROBiosystems
  • Size
  • Shipping
    RT
  • Price
  • 457,00 €
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