SARS-CoV-2 S protein RBD (N501Y), Fc Tag (MALS verified), Variant Lineage B.1.1.7

Molecular Weight: 51.1 kDa
Tag: Fc Tag
Source: SARS-CoV-2 S protein RBD (N501Y), Fc Tag (SPD-C5253) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (N501Y)). The N501Y mutaion was identified in multiple SARS-CoV-2 Variants of Concerns (VOCs), i.e. the Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01), the Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2), the Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3).
Purity: >95% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Powder
Additional Information
Synonyms: Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD
Organism: Other
Acc.No.: QHD43416.1 (N501Y)

Sequence Information

Arg 319 - Lys 537


It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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