SARS-CoV-2 Spike RBD (L452R, E484Q), His Tag (MALS verified) (B.1.617.1/B.1.617.3)

Molecular Weight: 28.3 kDa
Tag: His Tag & Avi Tag
Source: Biotinylated SARS-CoV-2 Spike RBD (L452R, E484Q), His,Avitag (SPD-C82Ec) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (L452R, E484Q)). The L452R, E484Q mutations were identified in the SARS-CoV-2 Delta variant (Pango lineage: B.1.617.2; other names: 21A/S:478K).
Purity: >95% as determined by SDS-PAGE.
Endotoxin Level: Less than 1.0 EU per μg by the LAL method.
Format: Powder
Additional Information
Synonyms: Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD
Organism: Other
Acc.No.: QHD43416.1 (L452R, E484Q)

Sequence Information

Arg 319 - Lys 537


It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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