CAS Number: 1243245-18-2
Formula: C24H25FN6O2
Format: Powder
Molecular Weight: 448.49
Purity: 98.00%


GNF-6231 shows IC50s of greater than 10 uM on all CYP isoforms tested . GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy. GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.  

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