GPI-1046

Datasheet
Specifications
CAS Number: 186452-09-5
Formula: C20H28N2O4
Format: Liquid Solution
Molecular Weight: 360.45
Purity: 98.00%

Description

GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models.GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. 

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