GW274150 phosphate

CAS Number: 438542-15-5
Formula: C8H20N3O6PS
Format: Powder
Molecular Weight: 317.3
Purity: 98.00%


GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation. GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 uM; Kd=40 nM) and rat iNOS (ED50=1.15 uM). 

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