I2906

Datasheet
Specifications
CAS Number: 331963-29-2
Formula: C25H37N3O4
Format: Powder
Molecular Weight: 443.58
Purity: 98.00%

Description

I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).

  • Catalog Number
    T11594-100mg-TM
  • Supplier
    TargetMol
  • Size
  • Shipping
    Blue Ice
  • Price
  • 156,00 €
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