GNAO1 Stably Expressing Immortalized Human Mammary Epithelial Cell Line
|Cell Category:||Drug Discovery Cell Lines|
|Tissue of Origin:||Skin|
GNAO1 Stably Expressing Immortalized Human Mammary Epithelial Cell line expresses GNAO1, the protein of which represent the alpha subunit of the G0 heterotrimeric G-protein signal-transducing complex and is partially responsible for smooth muscle contraction and depressing neuronal activity. They function to inhibit of adenylate cyclase , open K+-channels (via β/γ subunits), and close Ca2+-channels. Researchers may use this cell line to study G-protein signal-transducing pathways in humans. Defects in the GNAO1 gene are known as a cause of early-onset epileptic encephalopathy. This cell line was made using retrovirus transduction. It carries flag tag and expresses GFP.
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Genetically modified organism (GVO), see General Terms